Article
Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 1999
Swiderski R E, Reiter R S, Nishimura D Y, Alward W L, Kalenak J W, Searby C S, Stone E M, Sheffield V C, Lin J J
Abstract excerpt
The transcription factor FKHL7 gene has recently been associated with the anterior segment dysgenesis disorder of the eye known as Axenfeld-Rieger anomaly (ARA). A growing body of evidence indicates that mutations in FKHL7 cause not only defects in the anterior segment of the eye but defects in the heart valves and septa as well. In order to evaluate its contribution to normal heart septation and valve formation,...
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