Article
Cytotoxic chemotherapy and the evolution of cellular and viral resistance to antiretroviral therapy in HIV- infected individuals with lymphoma.
HIV clinical trials - 1 Sept 2016
McFaul Katie, Liptrott Neill, Cox Alison, Martin Phillip, Egan Deirdre, Owen Andrew, Kelly Sarah, Karolia Zeenat, Shaw Kate, Bower Mark, Boffito Marta
Abstract excerpt
BACKGROUND: The use of combination antiretroviral therapy (cART) and cytotoxic chemotherapy for HIV-associated lymphoma runs the risks of inducing HIV drug resistance. This study examined two possible mechanisms: altered expression of membrane drug transporter protein (MTP) and acquisition of mutations in pro-viral DNA. METHODS: Expression levels of MTP and pro-viral DNA resistance mutation analysis were...
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