Article
Combined analysis of polymorphisms of the tumor necrosis factor-alpha and interleukin-10 promoter regions and polymorphic xenobiotic metabolizing enzymes in psoriasis.
The Journal of investigative dermatology - 1 Aug 1999
Reich K, Westphal G, Schulz T, Müller M, Zipprich S, Fuchs T, Hallier E, Neumann C
Abstract excerpt
Environmental and genetic factors are thought to interact in the manifestation of psoriasis, but knowledge about the involved genes and antigens is incomplete. This study has focused on the association between psoriasis and inherited variations in xenobiotic metabolism and cytokine production as two components that may influence cutaneous immune responses to foreign substances. Polymorphisms of...
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