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Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2

1 Aug 1999

Abstract excerpt

Two types of strains of serotype I of infectious bursal disease virus (IBDV) have been described, on the basis of their ability (IBDV-TC) or inability (IBDV-BU) to infect chicken embryonic cells in culture. However, both types infect B lymphocytes in the bursa of Fabricius of young chickens. To determine the molecular basis for tissue culture infectivity, virus recombinants with chimeric segments A were...

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PMID: 10466805
DOI: 10.1099/0022-1317-80-8-2067

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