Article
Molecular determinants of virulence, cell tropism, and pathogenic phenotype of infectious bursal disease virus.
Journal of virology - 1 Dec 2001
Brandt M, Yao K, Liu M, Heckert R A, Vakharia V N
Abstract excerpt
Infectious bursal disease viruses (IBDVs), belonging to the family Birnaviridae, exhibit a wide range of immunosuppressive potential, pathogenicity, and virulence for chickens. The genomic segment A encodes all the structural (VP2, VP4, and VP3) and nonstructural proteins, whereas segment B encodes the viral RNA-dependent RNA polymerase (VP1). To identify the molecular determinants for the virulence, pathogenic...
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