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Alteration of amino acids in VP2 of very virulent infectious bursal disease virus results in tissue culture adaptation and attenuation in chickens

1 Jan 2002

Abstract excerpt

Reverse genetics technology offers the possibility to study the influence of particular amino acids of infectious bursal disease virus (IBDV) on adaptation to tissue culture. Genomic segments A and B of the very virulent (vv) IBDV field strain UK661 were completely cloned and sequenced, and the strain was rescued from full-length cDNA copies of both segments (UK661rev). Using site-directed mutagenesis, alteration...

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PMID: 11752708
DOI: 10.1099/0022-1317-83-1-121

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Alteration of amino acids in VP2 of very virulent infectious bursal disease virus results in tissue culture adaptation and attenuation in chickensPMID 11752708Read ↗

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Triplet amino acids located at positions 145/146/147 of the RNA polymerase of very virulent infectious bursal disease virus contribute to viral virulenceSemantic proximity Read ↗

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Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2Semantic proximity Read ↗

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