Article
Automated detection of prevalent mutations in BRCA1 and BRCA2 genes, using a fluorogenic PCR allelic discrimination assay.
Genetic testing - 1 Jan 2000
Abbaszadegan M R, Struewing J P, Brown K M, Snider J V, Goodsaid F, Gore-Langton R, Hughes M R
Abstract excerpt
Mutations in the genes BRCA1 and BRCA2 account for 5%-10% of familial early onset breast cancer. Identification of these mutations allows molecular diagnosis for breast cancer susceptibility. A high through-put automated PCR allelic discrimination assay (ADA) was developed to detect the prevalent...
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