Is the presence of retinopathy of practical value in defining cases of diabetic nephropathy in genetic association studies? The experience with the ACE insertion/deletion polymorphism in 53 studies comprising 17,791 subjects.

Abstract excerpt

OBJECTIVE: A key consideration when setting up genetic studies is the case definition. For diabetic nephropathy, the case definition is typically based on the presence of albuminuria. However, it has been long debated whether diabetic nephropathy cases defined in this way may have a high prevalence of nondiabetic kidney disease, especially if diabetic retinopathy is absent. RESEARCH DESIGN AND METHODS: We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Albuminuria
• Share to Diabetic Nephropathies