Article
Mitochondrial genome lesions in the pathogenesis of sporadic Alzheimer's disease.
Gerontology - 1 Jan 2000
Meier-Ruge W A, Bertoni-Freddari C
Abstract excerpt
BACKGROUND: The recent, magnificent results of molecular biology concerning beta-amyloid (betaA) metabolism in early onset Alzheimer's disease (AD) have generated a series of new findings and, in turn, a new etiological concept. Attention on the early events in the pathogenesis of AD has been shifted from the chromosomal abnormalities in the nucleus of nerve cells onto genetic changes in the mitochondrial genome....
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