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Article

A computational model to explore the role of angiogenic impairment on endochondral ossification during fracture healing.

Biomechanics and modeling in mechanobiology - 1 Oct 2016

OReilly Adam, Hankenson Kurt D, Kelly Daniel J

Abstract excerpt

While it is well established that an adequate blood supply is critical to successful bone regeneration, it remains poorly understood how progenitor cell fate is affected by the altered conditions present in fractures with disrupted vasculature. In this study, computational models were used to explore how angiogenic impairment impacts oxygen availability within a fracture callus and hence regulates mesenchymal...

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PMID: 26825534
DOI: 10.1007/s10237-016-0759-4

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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