Article
Molecular characterization of the 5' control region and of two lethal alleles affecting the hsp60 gene in Drosophila melanogaster.
FEBS letters - 6 Aug 1999
Perezgasga L, Segovia L, Zurita M
Abstract excerpt
The chaperonins are evolutionarily conserved essential cellular proteins that help folding newly synthesized or translocated proteins, spending ATP. We present here the molecular analysis of the hsp60 gene promoter region and of two Drosophila hsp60 ethyl methane sulfonate embryonic lethal alleles that have an identical phenotype. No heat shock element sequences were found in the 5' region, supporting previous...
Topics
- Alleles
- Animals
- Base Sequence
- Chaperonin 60
- Cloning, Molecular
- DNA, Complementary
- Drosophila melanogaster
- Ethyl Methanesulfonate
- Genes, Insect
- Genes, Lethal
- Models, Molecular
- Molecular Sequence Data
- Mutagens
- Open Reading Frames
- Point Mutation
- Promoter Regions, Genetic
- Protein Conformation
- RNA, Messenger