Article
Frequent multiplication of chromosome 1q in non-invasive and papillotubular carcinoma of the breast.
Cancer letters - 1 Jul 1999
Tsukamoto K, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Nakamura Y, Emi M
Abstract excerpt
Carcinogenesis is considered to be a multistep process that may involve cumulative genetic alterations; one of these mechanisms, gain of chromosomal material, has the potential to activate tumor-promoting genes in breast carcinogenesis. Using 12 polymorphic microsatellite markers on the long arm of chromosome 1 (1q), we examined 130 sporadic breast carcinomas for abnormalities in the copy numbers of these loci in...
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