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Article

Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients.

Biochemical and biophysical research communications - 11 Aug 1999

Nezu J, Oku A, Shimane M

Abstract excerpt

LKB1 Serine/Threonine (ST) kinase (also called STK11) originally identified in our novel protein kinase search project has recently been recognized as a susceptibility gene of Peutz-Jeghers Syndrome (PJS; MIM 175200). PJS is a dominantly inherited human disorder which is characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin pigmentation. Since PJS patients also show a predisposition...

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Source

Identifiers

PMID: 10441497
DOI: 10.1006/bbrc.1999.1047

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients.PMID 10441497Read ↗

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The molecular mechanisms that underlie the tumor suppressor function of LKB1.Semantic proximity Read ↗

LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.Semantic proximity Read ↗

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.Semantic proximity Read ↗

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.Semantic proximity Read ↗

Mutations in the human LKB1/STK11 gene.Semantic proximity Read ↗

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome.Semantic proximity Read ↗

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.Semantic proximity Read ↗

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndromeSemantic proximity Read ↗

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