Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.

European journal of pharmacology - 2 Jul 1999

Seki T, Awamura S, Kimura C, Ide S, Sakano K, Minami M, Nagase H, Satoh M

Abstract excerpt

We analyzed the pharmacological properties of 17-cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6b eta-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride (TRK-820) using Chinese hamster ovary (CHO) cells expressing cloned rat mu-, delta- and kappa-opioid receptors and human nociceptin receptor. TRK-820 showed high affinity for the kappa-opioid receptor, with a Ki value of 3.5 +/- 0.9 nM. In CHO...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Narcotic Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Radioligand Assay

Share to Receptors, Opioid

Share to Receptors, Opioid, delta

Share to Receptors, Opioid, kappa

Share to Receptors, Opioid, mu

Share to Spiro Compounds

Source

Identifiers

PMID: 10440101
DOI: 10.1016/s0014-2999(99)00369-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.PMID 10440101Read ↗

Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel β-arrestin-2-biased pathway.Semantic proximity Read ↗

(-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation.Semantic proximity Read ↗

Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor.Semantic proximity Read ↗

Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation.Semantic proximity Read ↗

A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.Semantic proximity Read ↗

Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors.Semantic proximity Read ↗

Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in mu-opioid receptor selectivity.Semantic proximity Read ↗

FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor.Semantic proximity Read ↗

Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.Semantic proximity Read ↗

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.Semantic proximity Read ↗

Different kinases desensitize the human delta-opioid receptor (hDOP-R) in the neuroblastoma cell line SK-N-BE upon peptidic and alkaloid agonists.Semantic proximity Read ↗

Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.