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Article

Optimized DNA extraction to improve reproducibility of short tandem repeat genotyping with highly degraded DNA as target.

Electrophoresis - 1 Jun 1999

Schmerer W M, Hummel S, Herrmann B

Abstract excerpt

The reproducibility of short tandem repeat (STR) genotyping of highly degraded DNA is often reduced due to artifacts generated during polymerase chain reaction (PCR) amplification. The frequency and amount of these artifacts are related to the quality and quantity of the DNA amplified. Consequently, the aim of this investigation was the optimization of DNA extraction to increase the reproducibility of STR...

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PMID: 10435436
DOI: 10.1002/(SICI)1522-2683(19990101)20:8<1712::AID-ELPS1712>3.0.CO;2-6

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