Article
STR-genotyping of archaeological human bone: experimental design to improve reproducibility by optimisation of DNA extraction.
Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur - 1 Mar 2000
Schmerer W M, Hummel S, Herrmann B
Abstract excerpt
The analysis of degraded DNA with the help of short tandem repeat loci (STRs) is an important source of information both in forensic casework and in the anthropological context. The reproducibility of STR-genotyping of highly degraded or "ancient" DNA can be reduced by the generation of artifacts during PCR amplification. The frequency and amount of these artifacts--allelic dropout and the generation of shadow...
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