Article
The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease.
Annals of neurology - 1 Aug 1998
Vaughan J, Durr A, Tassin J, Bereznai B, Gasser T, Bonifati V, De Michele G, Fabrizio E, Volpe G, Bandmann O, Johnson W G, Golbe L I, Breteler M, Meco G, Agid Y, Brice A, Marsden C D, Wood N W
Abstract excerpt
We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr mutation in the alpha-synuclein gene in an autosomal dominant Parkinson's disease kindred. No mutations were found from this broad white population, and we therefore c...
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA
- Europe
- Female
- Genetic Testing
- Humans
- Male
- Middle Aged
- Mutation
- Nerve Tissue Proteins
- Parkinson Disease
- Phosphoproteins