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Article

No pathogenic mutations in the persyn gene in Parkinson's disease.

Neuroscience letters - 4 Jan 1999

Lincoln S, Gwinn-Hardy K, Goudreau J, Chartier-Harlin M C, Baker M, Mouroux V, Richard F, Destée A, Becquet E, Amouyel P, Lynch T, Hardy J, Farrer M

Abstract excerpt

The persyn (gamma-synuclein) gene is highly homologous to the alpha-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to...

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PMID: 10027558
DOI: 10.1016/s0304-3940(98)00901-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10027558-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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No pathogenic mutations in the persyn gene in Parkinson's disease.PMID 10027558Read ↗

Mutations in the gene encoding human persyn are not associated with amyotrophic lateral sclerosis or familial Parkinson's disease.Semantic proximity Read ↗

No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.Semantic proximity Read ↗

Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease.Semantic proximity Read ↗

The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease.Semantic proximity Read ↗

No pathogenic mutations in the synphilin-1 gene in Parkinson's disease.Semantic proximity Read ↗

Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. The European Consortium on Genetic Susceptibility in Parkinson's Disease (GSPD)Semantic proximity Read ↗

Absence of the G209A mutation in the alpha-synuclein gene in British families with Parkinson's disease.Semantic proximity Read ↗

Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous SystemSemantic proximity Read ↗

Evaluation of the gamma-synuclein gene in German Parkinson's disease patients.Semantic proximity Read ↗

Genetic Analysis of Families with Parkinson Disease that Carry the Ala53Thr Mutation in the Gene Encoding α-SynucleinSemantic proximity Read ↗

Genetic analysis of synphilin-1 in familial Parkinson's disease.Semantic proximity Read ↗

Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson's disease in Finland.Semantic proximity Read ↗

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