Article
The genetics of signal transduction and the feto-maternal relationship. A study of cytosolic low molecular weight phosphotyrosine phosphatase.
Disease markers - 1 Nov 1998
Bottini E, Cosmi E, Nicotra M, Santeusanio G, La Torre M, Bottini N, Lucarini N
Abstract excerpt
Intracellular kinases mediate positive signalling from surface receptors by phosphorylating critical target proteins whereas phosphatases inhibit this process. Differential phosphatase activity at the feto-maternal interface could determine the appropriate relative growth and development on each side of the placenta. The highly polymorphic cytosolic low molecular weight phosphotyrosine-phosphatase...
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