Article
Identification of a 5-cM region of common allelic loss on 8p12-p21 in human breast cancer and genomic analysis of the hEXT1L/EXTR1/EXTL3 gene in this locus.
International journal of oncology - 1 Sept 1999
Suzuki A, Shao X, Song X Q, Hanaoka T, Irie S, Kashiwada M, Samara G, Close L G, Aoki T, Fujimori M, Ishikawa Y, Hatori M, Hosaka M, Sakurada A, Sato M, Ohuchi N, Satomi S, Fukushige S, Horii A, Sato T
Abstract excerpt
The short arm of chromosome 8 is frequently lost in many human carcinomas including breast cancer, suggesting the presence of a tumor suppressor gene(s) in this region. We identified a gene termed hEXT1L/EXTR1/EXTL3 (hEXT1L hereinafter) that was mapped to chromosome bands 8p12-p21 where frequent LOHs of this region was reported in breast cancer. The existence of the third breast cancer susceptibility gene was...
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