Alzheimer's and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches.

Abstract excerpt

Several lines of evidence suggest that a defective protein folding is a central event in both Alzheimer's and prion disease. Although the two disorders are very different clinically, neuropathologically, and biochemically, the molecular event that may trigger the disease process appears to be the same: the formation of an altered protein conformer composed of a high content of beta-sheet structure. Compounds with...

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