Article
One or more β-amyloid(s)? New insights into the prion-like nature of Alzheimer's disease.
Progress in molecular biology and translational science - 1 Jan 2020
Catania Marcella, Di Fede Giuseppe
Abstract excerpt
Misfolding and aggregation of proteins play a central role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's and Lewy Body diseases, Frontotemporal Lobar Degeneration and prion diseases. Increasing evidence supports the view that Aβ and tau, which are the two main molecular players in AD, share with the prion protein several "prion-like" features that can...
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