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Article

Correlation of the osteoblastic phenotype with prostate-specific antigen expression in metastatic prostate cancer: implications for paracrine growth.

The Journal of pathology - 1 Jul 1999

Doherty A, Smith G, Banks L, Christmas T, Epstein R J

Abstract excerpt

The characteristic sclerotic appearance of bone metastases from prostate cancer is unexplained but could involve excess peritumoural activity of osteoblast mitogens such as the insulin-like growth factors (IGFs). Since prostatic metastases are distinguished by androgen-dependent secretion of prostate-specific antigen (PSA), a serine protease which cleaves extracellular IGF-binding proteins and thereby enhances...

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Identifiers

PMID: 10419596
DOI: 10.1002/(SICI)1096-9896(199907)188:3<278::AID-PATH358>3.0.CO;2-G

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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