Article
Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2003
Fizazi Karim, Yang Jun, Peleg Sara, Sikes Charles R, Kreimann Erica L, Daliani Danai, Olive Matilde, Raymond Kevin A, Janus Todd J, Logothetis Christopher J, Karsenty Gerard, Navone Nora M
Abstract excerpt
PURPOSE: Prostate cancer specifically metastasizes to bone where it leads to bone formation. We previously reported that coculturing MDA PCa 2b prostate cancer cells with primary mouse osteoblasts (PMOs) induced PMO proliferation and differentiation. An osteoblastic reaction was also observed in vivo after injection of MDA PCa 2b cells into the bones of severe combined immunodeficient disease mice. The aim of...
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