Article

Notch3 Promotes Prostate Cancer-Induced Bone Lesion Development via MMP-3

2018-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and the bone microenvironment. Prostate cancer ce...

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Literature Corpus work: 7268ab26-5b04-5b9f-aa4c-6ff498a4c6ac
DOI: 10.1101/349043

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