Article

A mechanistic role for cardiac myocyte apoptosis in heart failure

2003-05-15

Abstract excerpt

Heart failure is a common, lethal condition whose pathogenesis is poorly understood. Recent studies have identified low levels of myocyte apoptosis (80–250 myocytes per 10(5) nuclei) in failing human hearts. It remains unclear, however, whether this cell death is a coincidental finding, a protective process, or a causal component in pathogenesis. Using transgenic mice that express a conditionally active caspase ex...

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Literature Corpus work: cc16edbd-e7ef-5bbe-b7ca-5e88b4ebc266
DOI: 10.1172/jci200317664

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