Article
A sensory neuron-specific, proton-gated ion channel.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Chen C C, England S, Akopian A N, Wood J N
Abstract excerpt
Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sens...
Topics
- Acid Sensing Ion Channels
- Alternative Splicing
- Amiloride
- Amino Acid Sequence
- Animals
- Base Sequence
- COS Cells
- Capsaicin
- Cloning, Molecular
- DNA Primers
- Degenerin Sodium Channels
- Epithelial Sodium Channels
- Ganglia, Spinal
- Gene Expression
- Genetic Variation
- In Situ Hybridization
- Ion Channel Gating
- Ion Channels