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Article

A sensory neuron-specific, proton-gated ion channel.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Chen C C, England S, Akopian A N, Wood J N

Abstract excerpt

Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons. Here, we describe the cloning and characterization of an ASIC splice variant, ASIC-beta, which contains a...

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Identifiers

PMID: 9707631
DOI: 10.1073/pnas.95.17.10240
PMCID: PMC21492

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