Article
Expression of exon v6-containing CD44 isoforms is related to poor prognosis of acute myelocytic leukemia.
Hematological oncology - 1 Dec 1998
Yokota A, Ishii G, Sugaya Y, Nishimura M, Saito Y, Harigaya K
Abstract excerpt
CD44 is a cell surface glycoprotein with a number of isoforms generated by alternative splicing of ten 'variant' exons in humans. Variant exon 6-containing isoforms of CD44 (CD44v6) have been implicated in the metastatic potential of rat carcinoma cell lines. Human homologues of CD44v6 are expressed in several tumour types and are involved in their progression. In the present study, we examined the expression of...
Topics
- Adolescent
- Adult
- Alternative Splicing
- Exons
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Glycoproteins
- Humans
- Hyaluronan Receptors
- Leukemia, Myeloid, Acute
- Male
- Middle Aged
- Prognosis
- Protein Isoforms
- Survival Analysis