Article
Characterization of CD44v6 isoforms in head-and-neck squamous-cell carcinoma.
International journal of cancer - 9 Sept 1999
van Hal N L, van Dongen G A, Stigter-van Walsum M, Snow G B, Brakenhoff R H
Abstract excerpt
CD44 splice variants, especially those containing the v6 domain, are assumed to play a critical role in the malignant progression of many human tumors. This concept was based on (i) the aberrant expression of CD44v6 in malignant cells, often encoded by alternatively spliced transcripts, and (ii) the absence of CD44v6 expression in corresponding normal tissues. Remarkably, data on CD44v6 expression in squamous...
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