Article
Definition of a high affinity growth hormone DNA response element.
Molecular and cellular endocrinology - 25 Apr 1999
Bergad P L, Towle H C, Berry S A
Abstract excerpt
Rat liver contains a growth hormone inducible nuclear factor complex, GHINF, that binds to the growth hormone response element (GHRE) of the serine protease inhibitor (Spi) 2.1 gene. GHINF contains Stat5 and binds to paired gamma-activated sites (GAS) within the GHRE, but poorly to either one alone. By analysis of the sequence of various GAS sites that bind the GHINF complex (based on the GHRE 3' GAS motif), we...
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