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Article

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing

12 Aug 1999

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (Lynch syndrome) is an autosomal dominant disease caused by mutations in the mismatch repair genes in particular in MLH1, MSH2 and MSH6. The disease is characterized by the development of colorectal, endometrial cancer and several other cancers. There is evidence that the clinical expression of the disease varies from one country to another. This variation might affect...

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Identifiers

PMID: 10404064
DOI: 10.1002/(sici)1097-0215(19990812)82:4<516::aid-ijc8>3.0.co;2-u

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