Article
Inosine(15.1) hammerhead ribozymes for targeting the transthyretin-30 mutation.
Biochemical and biophysical research communications - 5 Jul 1999
Pröpsting M J, Blaschke M, Haas R E, Genschel J, Hedrich H J, Manns M P, Schmidt H H
Abstract excerpt
The most common cause of hereditary amyloidosis (HA) is the val30met mutation in the transthyretin protein (TTR-met30). The mutation is caused by a mononucleic substitution from G to A (GUC to AUC) in the transthyretin gene resulting in the exchange for the amino acids valine to methionine in the corresponding protein sequence. The aim of our work was the development of a specific cleavage of TTR-30 mRNA using...
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