Brains and brawn: plectin as regulator and reinforcer of the cytoskeleton.

doi:10.1002/(SICI)1521-1878(199906)21:6<451::AID-BIES1>3.0.CO;2-B

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Article

Brains and brawn: plectin as regulator and reinforcer of the cytoskeleton.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 1999

Allen P G, Shah J V

Abstract excerpt

Plectin is a 580 kDa intracellular protein, previously shown to link intermediate filaments with microtubules, actin filaments, and membrane components. Disruption of the plectin gene in humans and in mice results in severe skin blistering and muscular degeneration, consistent with plectin's structural role in stabilizing cells against mechanical force. However, recent work by Andra et al. characterizing cells...

Topics

Actins
Animals
Brain
Cytoskeleton
Humans
Intermediate Filament Proteins
Mice
Phenotype
Phosphatidylinositol 4,5-Diphosphate
Plectin

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Identifiers

PMID: 10402951
DOI: 10.1002/(SICI)1521-1878(199906)21:6<451::AID-BIES1>3.0.CO;2-B

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