Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying Plectin Isoform Functions through Animal Models.

Cells - 17 Sept 2021

Castañón Maria J, Wiche Gerhard

Abstract excerpt

Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional complexes, organelles, and inner membrane systems. In addition, it interacts with actomyosin structures and microtubules. As a multifunctional protein, plectin has been implicated in several multisystemic diseases, the most common of which is epidermolysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Epidermolysis Bullosa Simplex
Share to Muscular Dystrophies, Limb-Girdle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Plectin

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 34572100
DOI: 10.3390/cells10092453
PMCID: PMC8468861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying Plectin Isoform Functions through Animal Models.PMID 34572100Read ↗

The many faces of plectin and plectinopathies: pathology and mechanisms.Semantic proximity Read ↗

Role of plectin in cytoskeleton organization and dynamicsSemantic proximity Read ↗

Plectin gene defects lead to various forms of epidermolysis bullosa simplex.Semantic proximity Read ↗

Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve.Semantic proximity Read ↗

Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.Semantic proximity Read ↗

Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.Semantic proximity Read ↗

Plectin and human genetic disorders of the skin and muscle. The paradigm of epidermolysis bullosa with muscular dystrophy.Semantic proximity Read ↗

Brains and brawn: plectin as regulator and reinforcer of the cytoskeleton.Semantic proximity Read ↗

Plectin defects in epidermolysis bullosa simplex with muscular dystrophy.Semantic proximity Read ↗

Plectin-Isoform-Specific Rescue of Hemidesmosomal Defects in Plectin (–/–) KeratinocytesSemantic proximity Read ↗

Plectin deficiency leads to both muscular dystrophy and pyloric atresia in epidermolysis bullosa simplex.Semantic proximity Read ↗

Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.