Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human acute myeloid leukemia cells with internal tandem duplications in the Flt3 gene show reduced proliferative ability in stroma supported long-term cultures.

Leukemia - 1 Jul 1999

Rombouts W J, Broyl A, Martens A C, Slater R, Ploemacher R E

Abstract excerpt

Recently, in-frame internal tandem duplications have been reported within the regions coding for the juxtamembrane through the first tyrosine kinase domain of the Flt3 gene. These duplications have been reported to lead to autophosphorylation of the receptor. In this study we investigated the effect of such mutations in the Flt3 gene on the in vitro proliferation of human acute myeloid leukemia cells. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid

Share to Receptor Protein-Tyrosine Kinases

Share to Receptors, Cell Surface

Share to Stromal Cells

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 10400423
DOI: 10.1038/sj.leu.2401446

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Human acute myeloid leukemia cells with internal tandem duplications in the Flt3 gene show reduced proliferative ability in stroma supported long-term cultures.PMID 10400423Read ↗

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines.Semantic proximity Read ↗

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.Semantic proximity Read ↗

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.Semantic proximity Read ↗

Lack of KIT or FMS internal tandem duplications but co-expression with ligands in AML.Semantic proximity Read ↗

Tyrosine kinase inhibitor insensitivity of non-cycling CD34+ human acute myeloid leukaemia cells with FMS-like tyrosine kinase 3 mutations.Semantic proximity Read ↗

Effects of FLT3 Ligand on Proliferation and Survival of Myeloid Leukemia CellsSemantic proximity Read ↗

The angioregulatory phenotype of native human acute myelogenous leukemia cells: influence of karyotype, Flt3 abnormalities and differentiation status.Semantic proximity Read ↗

Bone marrow stroma-mediated resistance to FLT3 inhibitors in FLT3-ITD AML is mediated by persistent activation of extracellular regulated kinase.Semantic proximity Read ↗

Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells.Semantic proximity Read ↗

Further activation of FLT3 mutants by FLT3 ligand.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.