Article
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.
Leukemia - 1 Sept 1998
Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T
Abstract excerpt
An internal tandem duplication (ITD) of the FLT3 gene is found in nearly 20% of acute myeloid leukemia (AML) and 5% of myelodysplastic syndrome cases. Our serial studies on 51 samples with the FLT3 gene mutation indicated that the ITD was frequently (47/51) clustered in the tyrosine-rich stretch...
Topics
- Acute Disease
- Animals
- COS Cells
- Chromosome Mapping
- Humans
- Leukemia, Myeloid
- Mutation
- Myelodysplastic Syndromes
- Neoplasm Proteins
- Phosphorylation
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- Receptors, Platelet-Derived Growth Factor
- Sequence Analysis
- fms-Like Tyrosine Kinase 3