Article
Tyrosine kinase inhibitor insensitivity of non-cycling CD34+ human acute myeloid leukaemia cells with FMS-like tyrosine kinase 3 mutations.
British journal of haematology - 1 Aug 2011
Alvares Caroline L, Schenk Tino, Hulkki Sanna, Min Toon, Vijayaraghavan Gowri, Yeung Jenny, Gonzalez David, So Chi W E, Greaves Mel, Titley Ian, Bartolovic Kerol, Morgan Gareth
Abstract excerpt
The efficacy of tyrosine kinase (TK) inhibitors on non-cycling acute myeloid leukaemia (AML) cells, previously shown to have potent tumourigenic potential, is unknown. This pilot study describes the first attempt to characterize non-cycling cells from a small series of human FMS-like tyrosine kinase 3 (FLT3) mutation positive samples. CD34+ AML cells from patients with FLT3 mutation positive AML were cultured on...
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