Article
p73 mutations and expression in adult de novo acute myelogenous leukemia.
Leukemia - 1 Jul 1999
Stirewalt D L, Clurman B, Appelbaum F R, Willman C L, Radich J P
Abstract excerpt
The p73 gene is a candidate tumor suppressor gene that has significant homology to p53. Thus far, p73 has not been investigated in hematopoietic malignancies. We used single-strand conformation polymorphism analysis to examine 60 de novo acute myelogenous leukemia (AML) patients for p73 mutations in exons 4, 6 and 7, which are homologous to the most frequently mutated exons in p53. Mutations were not found, but...
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