Article

<i>In vivo</i> analysis of UNC-23 reveals residues critical for BAG2 domain function

2026-05-28

Abstract excerpt

BAG2 is a co-chaperone that regulates Hsp70 activity and plays key roles in protein homeostasis and disease, yet the residue-level determinants of its stability and function remain poorly defined. Here, we use the Caenorhabditis elegans BAG2 homolog UNC-23 as an in vivo model to dissect these mechanisms. A forward genetic screen identified a missense mutation, UNC-23 C403Y , that causes muscle deterioration wit...

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Literature Corpus work: bc36735d-efeb-529d-8659-32f42303db88
DOI: 10.64898/2026.05.28.728440

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