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Article

A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.

Science (New York, N.Y.) - 2 Jul 1999

York J D, Odom A R, Murphy R, Ives E B, Wente S R

Abstract excerpt

In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Phosphotransferases (Alcohol Group Acceptor)

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Source

Identifiers

PMID: 10390371
DOI: 10.1126/science.285.5424.96

Genes

GLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.PMID 10390371Read ↗

Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.Semantic proximity Read ↗

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.Semantic proximity Read ↗

Dual functions for the Schizosaccharomyces pombe inositol kinase Ipk1 in nuclear mRNA export and polarized cell growth.Semantic proximity Read ↗

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.Semantic proximity Read ↗

The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.Semantic proximity Read ↗

The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region.Semantic proximity Read ↗

Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex.Semantic proximity Read ↗

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast.Semantic proximity Read ↗

InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis.Semantic proximity Read ↗

Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae.Semantic proximity Read ↗

The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit.Semantic proximity Read ↗

Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation.Semantic proximity Read ↗

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