Article
Identification and relevance of the CD95-binding domain in the N-terminal region of ezrin.
The Journal of biological chemistry - 5 Mar 2004
Lozupone Francesco, Lugini Luana, Matarrese Paola, Luciani Francesca, Federici Cristina, Iessi Elisabetta, Margutti Paola, Stassi Giorgio, Malorni Walter, Fais Stefano
Abstract excerpt
The CD95 (Fas/APO-1) linkage to the actin cytoskeleton through ezrin is an essential requirement for susceptibility to the CD95-mediated apoptosis in CD4+ T cells. We have previously shown that moesin was not involved in the binding to CD95. Here we further support the specificity of the ezrin/CD95 binding, showing that radixin did not bind CD95. The ezrin region specifically and directly involved in the binding...
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