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Article

Borrelia burgdorferiin Tick Cell Culture Modulates Expression of Outer Surface Proteins A and C in Response to Temperature

1 Jul 1999

Abstract excerpt

The Lyme disease spirochete Borrelia burgdorferi sensu stricto downregulates outer surface protein A (OspA) and upregulates outer surface protein C (OspC) during tick feeding. The switching of these proteins correlates with increased spirochetal infectivity for the mammal. We examined the effect of temperature on differential expression of OspA and OspC by B. burgdorferi cocultivated with a cell line isolated...

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Identifiers

PMID: 10364575
DOI: 10.1128/jcm.37.7.2137-2141.1999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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