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Article

Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.

The Journal of biological chemistry - 18 Jun 1999

Iost I, Dreyfus M, Linder P

Abstract excerpt

The Ded1 protein (Ded1p), a member of the DEAD-box family, has recently been shown to be essential for translation initiation in Saccharomyces cerevisiae. Here, we show that Ded1p purified from Escherichia coli has an ATPase activity, which is stimulated by various RNA substrates. Using an RNA strand-displacement assay, we show that Ded1p has also an ATP-dependent RNA unwinding activity. Hydrolysis of ATP is...

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Identifiers

PMID: 10364207
DOI: 10.1074/jbc.274.25.17677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.PMID 10364207Read ↗

Requirement of the DEAD-Box protein ded1p for messenger RNA translation.Semantic proximity Read ↗

Motif III in superfamily 2 "helicases" helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1.Semantic proximity Read ↗

Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs.Semantic proximity Read ↗

ATP hydrolysis activity of the DEAD box protein Rok1p is required for in vivo ROK1 function.Semantic proximity Read ↗

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.Semantic proximity Read ↗

The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.Semantic proximity Read ↗

Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1.Semantic proximity Read ↗

ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.Semantic proximity Read ↗

The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.Semantic proximity Read ↗

Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly.Semantic proximity Read ↗

Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes.Semantic proximity Read ↗

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