Article
Requirement of the DEAD-Box protein ded1p for messenger RNA translation.
Science (New York, N.Y.) - 7 Mar 1997
Chuang R Y, Weaver P L, Liu Z, Chang T H
Abstract excerpt
The DED1 gene, which encodes a putative RNA helicase, has been implicated in nuclear pre-messenger RNA splicing in the yeast Saccharomyces cerevisiae. It is shown here by genetic and biochemical analysis that translation, rather than splicing, is severely impaired in two newly isolated ded1 condi...
Topics
- Animals
- Cytoplasm
- DEAD-box RNA Helicases
- Eukaryotic Initiation Factor-4A
- Genes, Fungal
- Mice
- Mutation
- Peptide Initiation Factors
- Phenotype
- Protein Biosynthesis
- RNA Helicases
- RNA Nucleotidyltransferases
- RNA Splicing
- RNA, Fungal
- RNA, Messenger
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins