“Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated <i>shiverer</i> mouse brain

Abstract excerpt

Many diseases of the central nervous system (CNS), particularly those of genetic, metabolic, or infectious/inflammatory etiology, are characterized by "global" neural degeneration or dysfunction. Therapy might require widespread neural cell replacement, a challenge not regarded conventionally as amenable to neural transplantation. Mouse mutants characterized by CNS-wide white matter disease provide ideal models...