The myelin mutants as models to study myelin repair in the leukodystrophies.

doi:10.1007/s13311-011-0080-y

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Article

The myelin mutants as models to study myelin repair in the leukodystrophies.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2011

Duncan Ian D, Kondo Yoichi, Zhang Su-Chun

Abstract excerpt

The leukodystrophies are rare and serious genetic disorders of the central nervous system that primarily affect children who frequently die early in life or have significantly delayed motor and mental milestones that result in long-term disability. Although with some of these disorders, early intervention with bone marrow or cord blood transplantation has been proven useful, it has not yet been determined that...

Topics

Animals
Cell Transplantation
Demyelinating Diseases
Disease Models, Animal
Humans
Mice
Mice, Transgenic
Mutation
Myelin Sheath

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Identifiers

PMID: 21979830
DOI: 10.1007/s13311-011-0080-y
PMCID: PMC3250297

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