Article
Embryonic stem cell rescue of tremor and ataxia in myelin-deficient shiverer mice.
Journal of the neurological sciences - 15 Jan 2009
Low Hoi Pang, Gréco Béatrice, Tanahashi Yusuke, Gallant Judith, Jones Stephen N, Billings-Gagliardi Susan, Recht Lawrence D, Schwartz William J
Abstract excerpt
Transplantation of neural precursor cells has been proposed as a possible approach for replacing missing or damaged central nervous system myelin. Neonatal and adult myelin-deficient shiverer (shi) mice, bearing a mutation of the myelin basic protein (MBP) gene, have been used extensively as hosts for testing cell engraftment, migration, and myelination, but relatively little progress has been made in reversing...
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