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Article

Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA.

Journal of molecular biology - 11 Jun 1999

Zimmerly S, Moran J V, Perlman P S, Lambowitz A M

Abstract excerpt

Group II introns encode reverse transcriptases that function in both intron mobility and RNA splicing. The proteins bind specifically to unspliced precursor RNA to promote splicing, and then remain associated with the excised intron to form a DNA endonuclease that mediates intron mobility by target DNA-primed reverse transcription. Here, immunoblotting and UV cross-linking experiments show that the reverse...

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Source

Identifiers

PMID: 10356323
DOI: 10.1006/jmbi.1999.2778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA.PMID 10356323Read ↗

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The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.Semantic proximity Read ↗

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Balance between transcription and RNA degradation is vital for Saccharomyces cerevisiae mitochondria: reduced transcription rescues the phenotype of deficient RNA degradation.Semantic proximity Read ↗

Do DEAD-box proteins promote group II intron splicing without unwinding RNA?Semantic proximity Read ↗

The linear form of a group II intron catalyzes efficient autocatalytic reverse splicing, establishing a potential for mobility.Semantic proximity Read ↗

Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites.Semantic proximity Read ↗

Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron.Semantic proximity Read ↗

Group II intron mobility using nascent strands at DNA replication forks to prime reverse transcription.Semantic proximity Read ↗

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