Article
The linear form of a group II intron catalyzes efficient autocatalytic reverse splicing, establishing a potential for mobility.
RNA (New York, N.Y.) - 1 Mar 2009
Roitzsch Michael, Pyle Anna Marie
Abstract excerpt
Self-splicing group II introns catalyze their own excision from pre-RNAs, thereby joining the flanking exons. The introns can be released in a lariat or linear form. Lariat introns have been shown to reverse the splicing reaction; in contrast, linear introns are generally believed to perform no or only poor reverse splicing. Here, we show that a linear group II intron derived from ai5gamma can reverse the second...
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