Article
Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycin.
Molecular & general genetics : MGG - 1 Jan 2001
Lauer B, Russwurm R, Schwarz W, Kálmánczhelyi A, Bruntner C, Rosemeier A, Bormann C
Abstract excerpt
Six genes (nikP1, nikP2, nikS, nikT, nikU, and nikV) from Streptomyces tendae Tu901 were identified by analysis of the nucleotide sequence of the nikkomycin gene cluster. These genes, together with the previously described nikQ and nikR, span 9.39 kb and are transcribed as a polycistronic mRNA in a growth-phase-dependent manner. The nikP1 gene encodes a non-ribosomal peptide synthase consisting of an adenylation...
Topics
- Amino Acid Sequence
- Aminoglycosides
- Anti-Bacterial Agents
- Base Sequence
- Chromatography, High Pressure Liquid
- Genetic Complementation Test
- Models, Chemical
- Molecular Sequence Data
- Multigene Family
- Mutagenesis, Insertional
- Peptides
- Phenotype